CareLit · DOI-Nachweis · Klinische Pädiatrie
The miR-17–92 gene cluster is amplified and overexpressed in retinoblastoma
DOI 10.1055/s-0029-1222625
Bibliografische Angaben
Nachweis in CareLit
Autor:innenE Biewald, P Mestdagh, H Stephan, K de Preter, T Thor, M Baumann, D Lohmann, A Eggert, F Spelemann, A Schramm, J Vandesompele, JH Schulte
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aberrant microRNA expression is involved in the pathogenesis and progression of human malignancies, including embryonal tumors. Retinoblastoma is a common eye tumor of childhood and is mainly driven by mutations in the Rb1-gene. Genomic alterations observed in retinoblastoma also include amplification of chromosome 6p22. Neither high-resolution CGH nor miRNA expression have been investigated in primary retinoblastom…
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Zitierempfehlung
E Biewald, P Mestdagh, H Stephan, K de Preter, T Thor, M Baumann, D Lohmann, A Eggert, F Spelemann, A Schramm, J Vandesompele, JH Schulte (2009) The miR-17–92 gene cluster is amplified and overexpressed in retinoblastoma. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222625
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