CareLit · DOI-Nachweis · Klinische Pädiatrie
The Association Between STAT5a Activation, LEF-1 Down Regulation and Leukemic Transformation in Patients with Severe Congenital Neutropenia
DOI 10.1055/s-0029-1222640
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Gupta, J Skokowa, K Welte
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Congenital hematological disorders are excellent models for investigating the regulation of hematopoiesis in humans. Severe Congenital Neutropenia (CN) is a heterogeneous syndrome characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with no mature neutrophils in the peripheral blood. Even though G-CSF treatment results in increased neutrophil numbers in more than 90% of CN patients, G…
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Zitierempfehlung
K Gupta, J Skokowa, K Welte (2009) The Association Between STAT5a Activation, LEF-1 Down Regulation and Leukemic Transformation in Patients with Severe Congenital Neutropenia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222640
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