CareLit · DOI-Nachweis · Klinische Pädiatrie
Rational combination treatment targets different aspects of PAX3/FKHR oncogenicity
DOI 10.1055/s-0029-1222644
Bibliografische Angaben
Nachweis in CareLit
Autor:innenR Hecker, R Amstutz, FK Niggli, BW Schäfer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
PAX3/FKHR is an oncogenic transcription factor that acts through transcriptional deregulation of target genes, either by activation or repression. We have shown previously that the transcriptional activity of PAX3/FKHR on target genes such as AP2beta or CB1 depends on specific phosphorylation in a peptide located between the two DNA-binding domains. This activity can be targeted by multi-kinase inhibitors such as PK…
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Zitierempfehlung
R Hecker, R Amstutz, FK Niggli, BW Schäfer (2009) Rational combination treatment targets different aspects of PAX3/FKHR oncogenicity. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222644
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