CareLit · DOI-Nachweis · Klinische Pädiatrie
Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia
DOI 10.1055/s-0029-1222645
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Heitmann, D Reinhardt, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Children with Down syndrome (DS) are highly predisposed to acute myeloid leukemia (AML) and precedent transient leukemia (TL). For both malignancies mutations of the transcription factor GATA1 leading to the translation of the truncated variant GATA1s are a crucial event in the pathogenesis, but solitary insufficient for leukemogenesis. We compared global gene expression profiles of AML patient samples with and with…
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Zitierempfehlung
K Heitmann, D Reinhardt, JH Klusmann (2009) Gene expression-based chemical genomics identifies VPA to revert the oncogenic effect of GATA1s in Down syndrome leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222645
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