CareLit · DOI-Nachweis · Klinische Pädiatrie
Developmental stage-specific interplay between GATA1 and IGF signaling during fetal hematopoiesis and leukemogenesis
DOI 10.1055/s-0029-1222650
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJH Klusmann, FJ Godinho, K Heitmann, T Pushpanathan, D Reinhardt, SH Orkin, Z Li
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Fetal and adult hematopoiesis are distinct. Signaling pathways and their coordination with lineage-specific transcription during fetal hematopoiesis and their subversion during leukemogenesis are poorly understood. Down syndrome acute megakaryoblastic leukemia (AMKL) is characterized by a triad of fetal origin, mutated GATA1 (GATA1s), and trisomy 21, providing a unique model system to address these issues. We used a…
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Zitierempfehlung
JH Klusmann, FJ Godinho, K Heitmann, T Pushpanathan, D Reinhardt, SH Orkin, Z Li (2009) Developmental stage-specific interplay between GATA1 and IGF signaling during fetal hematopoiesis and leukemogenesis. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222650
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