CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of Potential Oncogenes on Chromosome 21 by RNA Interference Screening
DOI 10.1055/s-0029-1222652
Bibliografische Angaben
Nachweis in CareLit
Autor:innenML Koch, V Raghavan Thangapandi, D Reinhardt, JH Klusmann
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Children with Down syndrome (DS) have an increased risk to develop acute megakaryoblastic leukemia (AMKL). Acquired mutations in the hematopoietic transcription factor GATA1 are consistently present in DS-AMKL, but are insufficient to induce leukemia in the absence of trisomy 21. To identify genes on chromosome 21 which have the potential to contribute to leukemogenesis, we conducted a lentiviral shRNA screening in…
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Zitierempfehlung
ML Koch, V Raghavan Thangapandi, D Reinhardt, JH Klusmann (2009) Identification of Potential Oncogenes on Chromosome 21 by RNA Interference Screening. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222652
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