CareLit · DOI-Nachweis · Klinische Pädiatrie
Using the hematopoietic transplantation platform for TCR-engineered adoptive immunotherapy of leukemia
DOI 10.1055/s-0029-1222653
Bibliografische Angaben
Nachweis in CareLit
Autor:innenW Koestner, M Hapke, C Klein, K Welte, M Sauer
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Transfer of T cell receptor genes (TCR) directed against tumor-associated antigens can be used to circumvent tolerance and to increase the precursor frequency of tumor-reactive T cells. So far mainly autologous T cells have been used as a T cell source. In a recent clinical trial on melanoma patients (Morgan et. al. Science, 2006) prolonged in vivo survival of the transduced T cells seemed to be critical…
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Zitierempfehlung
W Koestner, M Hapke, C Klein, K Welte, M Sauer (2009) Using the hematopoietic transplantation platform for TCR-engineered adoptive immunotherapy of leukemia. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222653
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