CareLit · DOI-Nachweis · Klinische Pädiatrie
Identification of first and second genomic lesions in ETV6-RUNX1 positive childhood acute lymphoblastic leukaemia (ALL)
DOI 10.1055/s-0029-1222654
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Krumbholz, U Jacobs, S Semper, H von Goessel, T Langer, M Metzler
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: The ETV6-RUNX1 translocation, resulting from t(12;21)(p13;q22), is the most common chromosomal translocation in childhood ALL. The genomic ETV6-RUNX1 fusion site is unique to individual patients and represents an ideal molecular marker for absolute quantification. This chromosomal translocation (“first-hit“) alone is insufficient to induce leukemia, additional secondary genetic events (“second-hit“) are…
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Zitierempfehlung
M Krumbholz, U Jacobs, S Semper, H von Goessel, T Langer, M Metzler (2009) Identification of first and second genomic lesions in ETV6-RUNX1 positive childhood acute lymphoblastic leukaemia (ALL). Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222654
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