CareLit · DOI-Nachweis · Klinische Pädiatrie
Pharmacologic activation of the p53 pathway using Nutlin-3 inhibits medulloblastoma cell proliferation in vitro
DOI 10.1055/s-0029-1222655
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Künkele, M Baumann, A Odersky, H Deubzer, O Witt, A Eggert, A Schramm, JH Schulte
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In embryonal tumors including neuroblastoma, retinoblastoma and medulloblastoma, p53 is rarely mutated. Instead, the p53 pathway is functionally inactivated by other mechanisms such as overexpression of MDM2, which functions as an ubiquitin ligase regulating degradation of p53. Nutlin-3 is a small molecule inhibitor of the p53-MDM2 interaction. It is thereby stabilizing p53 and restoring its activity. Nutlin-3 has b…
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Zitierempfehlung
A Künkele, M Baumann, A Odersky, H Deubzer, O Witt, A Eggert, A Schramm, JH Schulte (2009) Pharmacologic activation of the p53 pathway using Nutlin-3 inhibits medulloblastoma cell proliferation in vitro. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222655
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