CareLit · DOI-Nachweis · Klinische Pädiatrie
The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients.
DOI 10.1055/s-0029-1222657
Bibliografische Angaben
Nachweis in CareLit
Autor:innenY Lippka, B Kumar Thakur, D Lan, J Skokowa, K Welte
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Severe congenital neutropenia is a heterogeneous disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5×10/l. G-CSF treatment increases blood neutrophil numbers in more than 90% of individuals with congenital neutropenia. CN is also considered as a pre-leukemic syndrome, since ca. 20% of CN patients dev…
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Zitierempfehlung
Y Lippka, B Kumar Thakur, D Lan, J Skokowa, K Welte (2009) The role of NAMPT/SIRT1/FOXO3a pathway for the leukemic transformation in severe congenital neutropenia (CN) patients. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222657
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