CareLit · DOI-Nachweis · Klinische Pädiatrie
EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation
DOI 10.1055/s-0029-1222669
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Plehm, A Fasan, S Rössler, R Unland, L Quintanilla-Martinez, MS Staege, C Müller-Tidow, S Burdach, GHS Richter
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Ewing Tumors (ET) are highly malignant, localized in bone or soft tissue and are molecularly defined by ews/ets translocations. DNA microarray analysis revealed a relationship of ET to both endothelium and fetal neural crest. We identified expression of histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) to be increased in ET. EZH2's suppressive activity maintains stemness in normal and malign…
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Zitierempfehlung
S Plehm, A Fasan, S Rössler, R Unland, L Quintanilla-Martinez, MS Staege, C Müller-Tidow, S Burdach, GHS Richter (2009) EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222669
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