CareLit · DOI-Nachweis · Klinische Pädiatrie
Oncogenic Potential of miR-125b-2 and its Target Genes in Normal and Malignant Hematopoesis
DOI 10.1055/s-0029-1222671
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Pushpanathan, J Klusmann, Z Li, K Böhmer, FJ Godinho, ML Koch, SH Orkin, D Reinhardt
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Children with Down Syndrome (DS) have increased risk for acute myeloid leukemia (AML), suggesting the presence of an additional copy of chromosome 21 is potentially oncogenic. We previously showed upregulation of chromosome 21 encoded miR-125b-2 in DS-AMKL. MiR-125b-2 increases the proliferation rate of hematopoietic stem and progenitor cells (HSPCs) while repressing myeloid differentiation, both in the murine and h…
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Zitierempfehlung
T Pushpanathan, J Klusmann, Z Li, K Böhmer, FJ Godinho, ML Koch, SH Orkin, D Reinhardt (2009) Oncogenic Potential of miR-125b-2 and its Target Genes in Normal and Malignant Hematopoesis. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222671
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