CareLit · DOI-Nachweis · Klinische Pädiatrie
NK cells engineered to express the chimeric receptor scFv(ch14.18)-zeta-specifically lyse GD2 expressing neuroectodermal tumors
DOI 10.1055/s-0029-1222682
Bibliografische Angaben
Nachweis in CareLit
Autor:innenD Seidel, N Huebener, D Pferdmenges, T Müller, W Wels, U Koehl, R Esser, M Bleeke, A Shibina, A Stermann, G Gaedicke, HN Lode
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Neuroblastoma (NB) and melanoma are neuroectodermal tumors characterized by poor prognosis. The T cell independent antigen ganglioside GD2 is highly expressed on most NB and on 30% of melanomas, which makes it an interesting target for immunotherapeutic approaches. NK cells are able to actively lyse tumors with downregulated MHC class I expression due to their MHC-independent target cell recognition. In order to pro…
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Zitierempfehlung
D Seidel, N Huebener, D Pferdmenges, T Müller, W Wels, U Koehl, R Esser, M Bleeke, A Shibina, A Stermann, G Gaedicke, HN Lode (2009) NK cells engineered to express the chimeric receptor scFv(ch14.18)-zeta-specifically lyse GD2 expressing neuroectodermal tumors. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222682
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