CareLit · DOI-Nachweis · Klinische Pädiatrie
MicroRNAs 221 and 222 in the Pathogenesis of Solid Childhood Tumors
DOI 10.1055/s-0029-1222693
Bibliografische Angaben
Nachweis in CareLit
Autor:innenT Thor, L Heukamp, H Hahn, R Kappler, R Buettner, A Eggert, A Schramm, JH Schulte
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
MYCN amplification is a common feature of aggressive neuroblastoma. MicroRNAs (miRNA) are a class of short RNAs that repress translation and promote mRNA degradation by sequence-specific interaction with target mRNAs. Previous studies have associated high expression of the co-regulated miR-221 and miR-222 with progression of various cancer entities. We identified miR-221 to be induced by MYCN in vitro and to correla…
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Zitierempfehlung
T Thor, L Heukamp, H Hahn, R Kappler, R Buettner, A Eggert, A Schramm, JH Schulte (2009) MicroRNAs 221 and 222 in the Pathogenesis of Solid Childhood Tumors. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222693
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