CareLit · DOI-Nachweis · Klinische Pädiatrie
Characterization of the t(7;12) chromosomal translocation in infant AMLs: coexpression of T-cell markers, distinct expression of homeobox genes and inhibition of the non-canonical Nf-kappaB pathway
DOI 10.1055/s-0029-1222697
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Nachweis in CareLit
Autor:innenS Wildenhain, J Hauer, S Röttgers, H Engelmann, V Binder, R Slany, WD Ludwig, J Harbott, A Borkhardt
ZeitschriftKlinische Pädiatrie
Ausgabe05/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Introduction: The chromosomal translocation t(7;12) was described in MLL negative acute myeloid leukemias of infancy associated with a very poor prognosis. The rearrangement involves the homeobox gene HLXB9 (7q36) and ETV6 (12p13). Methods: Leukemic bone marrow samples of 42 infants, diagnosed in Germany with AML and no 11q23 rearrangement were screened for the fusion transcript HLXB9/ETV6 with RT-PCR. Positive samp…
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Zitierempfehlung
S Wildenhain, J Hauer, S Röttgers, H Engelmann, V Binder, R Slany, WD Ludwig, J Harbott, A Borkhardt (2009) Characterization of the t(7;12) chromosomal translocation in infant AMLs: coexpression of T-cell markers, distinct expression of homeobox genes and inhibition of the non-canonical Nf-kappaB pathway. Klinische Pädiatrie (05). https://doi.org/10.1055/s-0029-1222697
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