CareLit · DOI-Nachweis · Geburtshilfe und Frauenheilkunde
Evaluation for synergistic suppression of breast cancer proliferation by Chloroquine in combination with the rapamycin derivative, Rad001
DOI 10.1055/s-0029-1225205
Bibliografische Angaben
Nachweis in CareLit
Autor:innenN Groh, I Brandt, MW Beckmann, M Schrauder, CR Loehberg
ZeitschriftGeburtshilfe und Frauenheilkunde
Ausgabe06/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Fragestellung: Breast cancer remains the most prevalent cancer among women in the Western world. Interactions between the p53 and the IGF-1/PI3K/Akt/mTOR pathway are present in many cancer cells. Therapeutical modification of each of these two pathways has been proven to exert anti-tumoral effects. The macrolide derivative of rapamycin Rad001 (everolimus) is an inhibitor of the serine-threonine kinase mTOR, and has…
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Zitierempfehlung
N Groh, I Brandt, MW Beckmann, M Schrauder, CR Loehberg (2009) Evaluation for synergistic suppression of breast cancer proliferation by Chloroquine in combination with the rapamycin derivative, Rad001. Geburtshilfe und Frauenheilkunde (06). https://doi.org/10.1055/s-0029-1225205
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