CareLit · DOI-Nachweis · Aktuelle Neurologie
In double-transgenic mouse models non-expanded ataxin-3 not suppresses polyglutamine neurodegeneration in the SCA3 disease – in vivo evidence
DOI 10.1055/s-0029-1238349
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Nachweis in CareLit
Autor:innenJ Hübener, O Riess
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Central questions in polyQ-induced neurodegeneration are the influence of the function of the non-expanded and the disease protein, the formation of aggregates, and the modulation by quality control mechanisms (e.g. unfolded protein response, ERAD or ubiquitin proteasome pathway). To answer the question of the interaction of a non-expanded allele with an expanded polyQ stretch in vivo we generated double-transgenic…
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Zitierempfehlung
J Hübener, O Riess (2009) In double-transgenic mouse models non-expanded ataxin-3 not suppresses polyglutamine neurodegeneration in the SCA3 disease – in vivo evidence. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238349
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