CareLit · DOI-Nachweis · Aktuelle Neurologie
Active immunisation with amyloid-β 1–42 severely impairs memory performance in healthy mice through TLR 2/4-dependent activation of the innate immune system
DOI 10.1055/s-0029-1238380
Bibliografische Angaben
Nachweis in CareLit
Autor:innenP Vollmar, JS Kullmann, B Thilo, MC Claussen, H Jacobi, B Wolff, SR Kalluri, HP Hartung, S Nessler, B Hemmer
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Active immunization with Aβ 1–42 was shown to prevent amyloid plaque deposition in the CNS. However, immunization with Aβ 1–42 may cause meningoencephalitis in human or an experimental autoimmune encephalomyelitis (EAE)-like disease in mice. Recently, we identified cognitive impairment and changes in psychomotor behavior in healthy C57/BL6 mice challenged with active Aβ 1–42 immunization. Immunohistochemistry and ge…
Zitieren
Zitierempfehlung
P Vollmar, JS Kullmann, B Thilo, MC Claussen, H Jacobi, B Wolff, SR Kalluri, HP Hartung, S Nessler, B Hemmer (2009) Active immunisation with amyloid-β 1–42 severely impairs memory performance in healthy mice through TLR 2/4-dependent activation of the innate immune system. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238380
Mit CareLit weiterarbeiten