CareLit · DOI-Nachweis · Aktuelle Neurologie
In vivo assessment of neuronal dysfunction in rats transgenic for Huntington's disease using small animal FDG-PET and MRI – a 16 months follow-up study
DOI 10.1055/s-0029-1238559
Bibliografische Angaben
Nachweis in CareLit
Autor:innenV Lippross, S Hermann, N Nagelmann, J Heselhaus, S Bohlen, H Kugel, M Deppe, J Sommer, C Bremer, H Nguyen, O Riess, S von Hörsten, M Schäfers, R Reilmann
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: Huntington's Disease (HD) is a dominant neurodegenerative disorder. Human FDG-PET and MRI imaging show functional changes and signs of atrophy in the striatum, even in pre-manifest HD. Transgenic animal models of HD provide invaluable insights into disease mechanisms and may facilitate evaluation of new therapeutic targets. Several established rodent models, e.g., the R6/2 and YAC-128 mice, carry CAG-rep…
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Zitierempfehlung
V Lippross, S Hermann, N Nagelmann, J Heselhaus, S Bohlen, H Kugel, M Deppe, J Sommer, C Bremer, H Nguyen, O Riess, S von Hörsten, M Schäfers, R Reilmann (2009) In vivo assessment of neuronal dysfunction in rats transgenic for Huntington's disease using small animal FDG-PET and MRI – a 16 months follow-up study. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238559
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