CareLit · DOI-Nachweis · Aktuelle Neurologie
Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischaemic stroke due to a ceiling effect of enzymatic activity in brain
DOI 10.1055/s-0029-1238662
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Nachweis in CareLit
Autor:innenF Leypoldt, M Gelderblom, CU Choe, EC von Leitner, D Atzler, E Schwedhelm, C Gerloff, C Sydow, R Böger, T Magnus
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Purpose: Methylated arginines are endogenous analogues of L-arginine, the substracte for NO synthase. Asymmetric dimethylarginine (ADMA) interferes with nitric oxide (NO) formation, causing endothelial dysfunction. ADMA is a predictor of cardiovascular events and mortality in humans. It is eliminated primarily by enzymatic activity of dimethylarginine dimethylaminohydrolase (DDAH). Methods: We investi…
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Zitierempfehlung
F Leypoldt, M Gelderblom, CU Choe, EC von Leitner, D Atzler, E Schwedhelm, C Gerloff, C Sydow, R Böger, T Magnus (2009) Dimethylarginine dimethylaminohydrolase-1 transgenic mice are not protected from ischaemic stroke due to a ceiling effect of enzymatic activity in brain. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238662
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