CareLit · DOI-Nachweis · Aktuelle Neurologie
Valproic acid impairs astroglial differentiation of neural stem cells by inhibition of PI3-kinase/Akt/NFkB pathway
DOI 10.1055/s-0029-1238665
Bibliografische Angaben
Nachweis in CareLit
Autor:innenM Kowalski, J Buddensiek, U Runge, A Storch, M Sabolek
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: VPA is a known inhibitor of PI3-kinase/Akt pathway. Inhibitory effects on GSK-3 (downstream effector of PI3-kinase), as well as direct effects on PI3-kinase are reported. Own previous studies showed that wortmannin (PI3-kinase inhibitor) and SN50 (NFkB-inhibitor) blocked astroglial differentiation of mesencephalic neural stem cells (NSCs). Neural differentiation promoting effects of VPA are as well discu…
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Zitierempfehlung
M Kowalski, J Buddensiek, U Runge, A Storch, M Sabolek (2009) Valproic acid impairs astroglial differentiation of neural stem cells by inhibition of PI3-kinase/Akt/NFkB pathway. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238665
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