CareLit · DOI-Nachweis · Aktuelle Neurologie
Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity
DOI 10.1055/s-0029-1238667
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Nachweis in CareLit
Autor:innenJ Lewerenz, R Dargusch, P Maher
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
In cerebral ischemia, reduced blood flow results in lactate accumulation and subsequent tissue acidosis. Lactate and acidosis have been demonstrated to increase infarct size in humans and in animal models of cerebral ischemia. Oxidative glutamate toxicity is a form of glutamate-induced nerve cell death, where glutamate inhibits cystine uptake via the cystine/glutamate antiporter system xc-. Cystine is an essential b…
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Zitierempfehlung
J Lewerenz, R Dargusch, P Maher (2009) Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238667
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