CareLit · DOI-Nachweis · Aktuelle Neurologie
The anti-inflammatory drug CNI-1493 regulates the intracellular processing of Aβ in different cell types of the brain
DOI 10.1055/s-0029-1238668
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Autor:innenD Mengel, JP Bach, Y Al-Abed, R Dodel, M Bacher
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Recently, we have reported that the potent anti-inflammatory p38-MAPK-inhibitor CNI-1493 is capable to decrease the extracellular Aβ production in vitro (Bacher et al., J Exp Med. 2008). This phenomenon-was also confirmed by our in vivo experiment showing that the soluble Aβ fraction was markedly reduced in an APP transgenic mouse model following CNI-1493 administration. One possible explanation for the CNI-1493 dep…
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Zitierempfehlung
D Mengel, JP Bach, Y Al-Abed, R Dodel, M Bacher (2009) The anti-inflammatory drug CNI-1493 regulates the intracellular processing of Aβ in different cell types of the brain. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238668
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