CareLit · DOI-Nachweis · Aktuelle Neurologie
Antioxidative and tumourigenic phenotype of frataxin-expressing glioma cells
DOI 10.1055/s-0029-1238746
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Autor:innenA Höfer, E Kirches, C Mawrin
ZeitschriftAktuelle Neurologie
Ausgabe10/2009
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Introduction: The mitochondrial protein frataxin (FRX) is thought to be involved in Fe/S-cluster biogenesis. Reduced expression due to gene mutation in patients with Friedreich's ataxia leads to dis-turbed mitochondrial iron homeostasis and oxidative stress. In xenografted carcinoma cells and a hepatocyte-specific knockout mouse, FRX had shown tumor suppressor features. We analyzed the role of FRX in gliomas. Method…
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Zitierempfehlung
A Höfer, E Kirches, C Mawrin (2009) Antioxidative and tumourigenic phenotype of frataxin-expressing glioma cells. Aktuelle Neurologie (10). https://doi.org/10.1055/s-0029-1238746
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