CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in-vivo and in-vitro models
DOI 10.1055/s-0029-1241500
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Nachweis in CareLit
Autor:innenW Schneiderhan, M Scheler, KH Holzmann, M Marx, JE Gschwend, M Bucholz, T Gress, T Seufferlein, G Adler, F Oswald
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
CD147 (Basigin, EMMPRIN) is a multifunctional, highly conserved glycoprotein enriched in pancreatic ductal adenocarcinomas (PDAC). CD147 expression has been associated to poor prognosis in many malignancies. To clarify the role of CD147 in pancreatic cancer we silenced CD147 in PDAC cells. Interestingly, CD147 RNAi significantly reduced the cell proliferation rate. CD147 is required for expression and function of mo…
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Zitierempfehlung
W Schneiderhan, M Scheler, KH Holzmann, M Marx, JE Gschwend, M Bucholz, T Gress, T Seufferlein, G Adler, F Oswald (2009) CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in-vivo and in-vitro models. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0029-1241500
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