CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Ethanol-induced cytochrome P450 2E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease
DOI 10.1055/s-0029-1241568
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Nachweis in CareLit
Autor:innenG Millonig, Y Wang, J Nair, E Patsenker, F Stickel, S Mueller, H Bartsch, HK Seitz
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Oxidative stress is thought to play a major role in the pathogenesis of hepatocellular cancer (HCC), the most frequent complication of alcoholic liver disease (ALD). However, its underlying mechanisms are poorly understood. In hepatocytes of patients with ALD, we could recently detect significant levels of carcinogenic exocyclic etheno-DNA adducts that are formed by the reaction of the lipid peroxidation produ…
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Zitierempfehlung
G Millonig, Y Wang, J Nair, E Patsenker, F Stickel, S Mueller, H Bartsch, HK Seitz (2009) Ethanol-induced cytochrome P450 2E1 causes carcinogenic etheno-DNA lesions in alcoholic liver disease. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0029-1241568
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