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Ursodeoxycholic acid suppresses the transcription of genes responsible for proliferation in the normal intestinal epithelial cells in vivo and in vitro

S Krishna-Subramanian, C Loddenkemper, ML Hanski, M Zeitz, C Hanski · Zeitschrift für Gastroenterologie · Ausgabe 09/2009

DOI 10.1055/s-0029-1241644

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Autor:innenS Krishna-Subramanian, C Loddenkemper, ML Hanski, M Zeitz, C Hanski
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2009
Jahrgang / SeitenNicht angegeben

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Introduction: Ursodeoxycholic acid (UDCA) prevents colitis-related colon cancer which potentially can be attributed to enhanced proliferation during tissue regeneration. We investigated therefore the effects of UDCA on growth of normal rodent intestinal epithelial cells and on the expression of proliferation-relevant genes. Materials and methods: Two groups of six C57BL/6J mice were fed with standard diet with and w…

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S Krishna-Subramanian, C Loddenkemper, ML Hanski, M Zeitz, C Hanski (2009) Ursodeoxycholic acid suppresses the transcription of genes responsible for proliferation in the normal intestinal epithelial cells in vivo and in vitro. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0029-1241644

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