CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Dual silencing of IGF-I receptor and EGF receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
DOI 10.1055/s-0029-1241650
Bibliografische Angaben
Nachweis in CareLit
Autor:innenS Kaulfuss, J Gaedcke, P Burfeind, JG Scharf
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe09/2009
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Overexpression and/or activation of tyrosine kinase receptors are common features of colorectal cancer (CRC). Using the human CRC cell lines DLD-1 and Caco-2, we evaluated the role of the IGF-I receptor (IGF-IR) and EGF receptor (EGFR) in cellular functions of these cells. We used the small interfering RNA (siRNA) technology to specifically down-regulate IGF-IR and EGFR expression. Knockdown of IGF-IR and EGFR resul…
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Zitierempfehlung
S Kaulfuss, J Gaedcke, P Burfeind, JG Scharf (2009) Dual silencing of IGF-I receptor and EGF receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. Zeitschrift für Gastroenterologie (09). https://doi.org/10.1055/s-0029-1241650
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