CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Ergocalciferol significantly inhibits profibrogenic and proinflammatory gene expression by hepatic stellate cells: Ergocalciferol a potential supplement in the therapy of liver fibrosis
DOI 10.1055/s-0029-1246332
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Autor:innenA Beilfuss, R Gieseler, G Marquitan, P Kocabayoglu, A Zahn, G Gerken, SL Friedman, AE Canbay
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: Patients with Fibrosis exhibit Vitamin-D (VD) deficiency. HSC store VD, express the VD-Receptor1 (VDR1) and play a key role in hepatic fibrogenesis. Thus we studied the effect of VD and its derivatives on HSC. Methods: LX2 cells were treated with VD2 (10–6 M), 25-hydroxyvitamin D3 (25VD; 10–7 M), or 1,25-dihydroxyvitamin D3 (1,25VD; 10–8 M) for 24 or 48h. Expression of α-SMA, COL1A, TGF-β, MCP1, PDGFR, VDR and…
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Zitierempfehlung
A Beilfuss, R Gieseler, G Marquitan, P Kocabayoglu, A Zahn, G Gerken, SL Friedman, AE Canbay (2010) Ergocalciferol significantly inhibits profibrogenic and proinflammatory gene expression by hepatic stellate cells: Ergocalciferol a potential supplement in the therapy of liver fibrosis. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246332
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