CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
TGF-β/Smad-1 signaling activates regenerative pro-survival mechanisms, whereas TGF-β/Smad-2/3 leads to pro-apoptotic programs in primary mouse hepatocytes
DOI 10.1055/s-0029-1246336
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Nachweis in CareLit
Autor:innenK Breitkopf, A Müller, I Ilkavets, S Dooley
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Phosphorylation of the signaling molecules Smad2/3 is considered as classical TGF-β signal transduction pathway. However, in an increasing number of cell types, including endothelial cells, hepatocytes and hepatic stellate cells, TGF-β phosphorylates Smad1, originally dedicated as BMP responsive branch. Since no discrimination of these parallel pathways was done up to now in liver cells, aim of the present study was…
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Zitierempfehlung
K Breitkopf, A Müller, I Ilkavets, S Dooley (2010) TGF-β/Smad-1 signaling activates regenerative pro-survival mechanisms, whereas TGF-β/Smad-2/3 leads to pro-apoptotic programs in primary mouse hepatocytes. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246336
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