CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Role of ERK1/2/MAPK and cFLIP Signalling in Apoptosis Suppression by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE)
DOI 10.1055/s-0029-1246338
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Nachweis in CareLit
Autor:innenW Chamulitrat, A Pathil, W Stremmel
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
We had synthesized the bile acid-phospholipid conjugate UDCA-LPE which was demonstrated to be cytoprotective against TNF-α-induced apoptosis with a mechanism involving cFLIP/caspase 8 signalling. We found that UDCA-LPE activated ERK1/2 phosphorylation. It is known that ERK1/2/MAPK pathway regulates cellular survival and apoptosis, we now ask a question whether ERK1/2 could regulate cFLIP during intrinsic apoptosis.…
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Zitierempfehlung
W Chamulitrat, A Pathil, W Stremmel (2010) Role of ERK1/2/MAPK and cFLIP Signalling in Apoptosis Suppression by Ursodeoxycholyl Lysophosphatidylethanolamide (UDCA-LPE). Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246338
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