CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Endoglin modulates Smad-dependent and Smad-independent pathways to regulate proliferation, migration and profibrogenic responses in myofibroblasts
DOI 10.1055/s-0029-1246352
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Autor:innenE Kovalenko, L Tihaa, SK Meurer, R Weiskirchen
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: TGF-β1-mediated transdifferentiation of hepatic stellate cells (HSC) to myofibroblast-like cells (MFB) is the key event to initiate the fibrogenic program in the liver. This comprises upregulation of contractile elements, e.g. α-SMA, increased expression of collagen type I and connective tissue growth factor (CTGF) as well as a higher proliferation and migration rate [1]. To determine the factors that govern m…
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Zitierempfehlung
E Kovalenko, L Tihaa, SK Meurer, R Weiskirchen (2010) Endoglin modulates Smad-dependent and Smad-independent pathways to regulate proliferation, migration and profibrogenic responses in myofibroblasts. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246352
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