CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Inhibitory effects of 1,7-dimethylxanthine (paraxanthine) on TGF-beta (Smad2/3) signaling in transdifferentiating rat hepatic stellate cells
DOI 10.1055/s-0029-1246354
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Autor:innenB Lahme, OA Gressner
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background and Aim: Based on reports of a hepatoprotective effect of coffee consumption, we were the first to give evidence that caffeine suppresses TGF-β dependent Smad signaling and target gene (e.g. CTGF) induction in hepatocytes. Ongoing investigations finally identified the primary caffeine metabolite paraxanthine (1,7-dimethylxanthine; 1,7-DMX) as the most potent xanthine-derived inhibitor of TGF-β signaling i…
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Zitierempfehlung
B Lahme, OA Gressner (2010) Inhibitory effects of 1,7-dimethylxanthine (paraxanthine) on TGF-beta (Smad2/3) signaling in transdifferentiating rat hepatic stellate cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246354
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