CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
IL-13 induces CTGF expression via a TGF-β independent mechanism in hepatic stellate cells
DOI 10.1055/s-0029-1246355
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Autor:innenY liu, C Meyer, H Shen, A Müller, MV Singer, S Dooley, HL Weng
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
Aims: In liver, connective tissue growth factor (CTGF) is a critical mediator of TGF-β dependent fibrogenesis, with a particular role in stimulating extracellular matrix production and hepatic stellate cell (HSC) activation. IL-13 is mainly produced by Th2 cells and is recognised as a crucial profibrotic cytokine in liver. Although the fibrotic function of IL-13 was well studied in murine models, especially in Schis…
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Zitierempfehlung
Y liu, C Meyer, H Shen, A Müller, MV Singer, S Dooley, HL Weng (2010) IL-13 induces CTGF expression via a TGF-β independent mechanism in hepatic stellate cells. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246355
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