CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Hepatocyte-specific NEMO deletion in mice leads to oxidative stress lethality during liver regeneration
DOI 10.1055/s-0029-1246356
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Autor:innenY Malato, N Beraza, H Ehedego, N Gassler, C Liedtke, C Trautwein
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
NEMO is the regulatory subunit of the IKK complex activating the transcription factor NF-KB. Hepatocyte-specific NEMO knock-out (NEMOΔhepa) animals show a complete inhibition of NF-KB signalling in parenchymal cells leading to a severe phenotype. As NF-KB is involved in early events of hepatocyte proliferation, we studied the impact of hepatocyte-specific NEMO deletion on liver regeneration. All wt animals survived…
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Zitierempfehlung
Y Malato, N Beraza, H Ehedego, N Gassler, C Liedtke, C Trautwein (2010) Hepatocyte-specific NEMO deletion in mice leads to oxidative stress lethality during liver regeneration. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246356
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