CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
ER-stress activation in human hepatocellular cancer cells: an alternative death pathway induced by the pan-deacetylase inhibitor panobinostat
DOI 10.1055/s-0029-1246379
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Nachweis in CareLit
Autor:innenP Di Fazio, R Montalbano, K Quint, S Gahr, T Wissniowski, M Ocker
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Background: We previously showed that panobinostat, a novel pan-deacetylase inhibitor, has a potent apoptotic activity in vitro and induces growth delay of HCC xenografts in nude mice. Panobinostat is able to induce cell death in HepG2 (p53wt) and in Hep3B (p53null) cell lines that is not dependent on canonical apoptotic pathways. Here we analyse the effect on ER-stress by panobinostat treatment. Methods: HepG2 and…
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Zitierempfehlung
P Di Fazio, R Montalbano, K Quint, S Gahr, T Wissniowski, M Ocker (2010) ER-stress activation in human hepatocellular cancer cells: an alternative death pathway induced by the pan-deacetylase inhibitor panobinostat. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246379
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