CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates inflammation and fibrosis in experimental NASH in vivo
DOI 10.1055/s-0029-1246397
Bibliografische Angaben
Nachweis in CareLit
Autor:innenK Dostert, R Wiest, J Schoelmerich, C Hellerbrand, E Gäbele
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: Non-alcoholic steatohepatitis (NASH) leads to liver fibrosis characterized by activation of hepatic stellate cells (HSC) and collagen expression. In vitro, we were able to show that PI3K, an ubiquitary, heterodimeric lipid kinase, participates in HSC proliferation and collagen expression (J Biol Chem 2005; 280(14): 13374–82). Further, PI3K is a key component of the insulin signalling pathway. Therefore, the ai…
Zitieren
Zitierempfehlung
K Dostert, R Wiest, J Schoelmerich, C Hellerbrand, E Gäbele (2010) Deficiency of phosphatidylinositol 3-kinase (PI3K) aggravates inflammation and fibrosis in experimental NASH in vivo. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246397
Mit CareLit weiterarbeiten