CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Comparative analysis of Phase I and II Enzyme Activities in 6 Hepatoma Cell Lines Identifies Huh-7 Cells with the highest Potential to study Drug Metabolism
DOI 10.1055/s-0029-1246399
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Autor:innenS Ehnert, J Lin, N Nussler, L Liu, AK Nussler
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Gold standard to perform human drug metabolism studies is primary human hepatocytes. Their availability is limited by donor organ scarcity. Hepatoma cell lines are widely used as an alternative. Although, phase I and II drug metabolizing activities of these cell lines are substantially lower than in primary hepatocytes, their major advantage is immediate availability, standard culture conditions and unlimited life-s…
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Zitierempfehlung
S Ehnert, J Lin, N Nussler, L Liu, AK Nussler (2010) Comparative analysis of Phase I and II Enzyme Activities in 6 Hepatoma Cell Lines Identifies Huh-7 Cells with the highest Potential to study Drug Metabolism. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246399
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