CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Targeting of P53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by P53-homologues
DOI 10.1055/s-0029-1246422
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Autor:innenF Kühnel, E Gürlevik, T Wirth, N Malek, M Müller-Schilling, M Manns, L Zender, S Kubicka
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
A hallmark of hepatocellular carcinomas is the loss of p53 or its transcriptional functions. In this study we describe the generation of the conditionally-replicating adenovirus Adp53sensor for the treatment of p53-dysfunctional HCC. p53-selective attenuation of viral replication was achieved by using p53-dependent expression of the transcriptional repressor GAL4-KRAB that was directed against the adenoviral E1A loc…
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Zitierempfehlung
F Kühnel, E Gürlevik, T Wirth, N Malek, M Müller-Schilling, M Manns, L Zender, S Kubicka (2010) Targeting of P53-transcriptional dysfunction by conditionally replicating adenovirus is not limited by P53-homologues. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246422
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