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Tumor vaccination during oncolytic inflammation leads to regulatory T cell-dependent virus/tumor immune interference that facilitates effective cancer immunotherapy

N Woller, B Mundt, E Gürlevik, M Manns, L Zender, T Wirth, F Kühnel, S Kubicka · Zeitschrift für Gastroenterologie · Ausgabe 01/2010

DOI 10.1055/s-0029-1246468

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Autor:innenN Woller, B Mundt, E Gürlevik, M Manns, L Zender, T Wirth, F Kühnel, S Kubicka
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

A balance between effector and suppressor mechanisms dictates whether an infection would overcome tolerance mechanism to trigger autoimmunity. In order to shift this balance in favor of antitumoral immunity we performed vaccinations with tumor-antigen loaded dendritic cells before, during or after oncolytic inflammation of a primary tumor. We observed a strongly enhanced antitumoral CD8+ T cell immune response which…

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Zitierempfehlung

N Woller, B Mundt, E Gürlevik, M Manns, L Zender, T Wirth, F Kühnel, S Kubicka (2010) Tumor vaccination during oncolytic inflammation leads to regulatory T cell-dependent virus/tumor immune interference that facilitates effective cancer immunotherapy. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246468

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