CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Combined activation signalling breaks established CD8+ T cell tolerance and results in effector CTL generation
DOI 10.1055/s-0029-1246499
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Autor:innenJ Böttcher, D Stabenow, S Hegenbarth, P Knolle, L Diehl
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
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Abstract-Vorschau
In the liver, soluble and gut-derived antigens are efficiently taken up by the resident antigen presenting cells, the liver sinusoidal endothelial cells (LSEC). Importantly, LSEC are capable of cross-presenting these antigens on MHC class I molecules to naïve CD8+ T cells. This cross-presentation results in the induction of antigen-specific T cell tolerance and the generation of a unique, tolerant CD8+ T cell subset…
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Zitierempfehlung
J Böttcher, D Stabenow, S Hegenbarth, P Knolle, L Diehl (2010) Combined activation signalling breaks established CD8+ T cell tolerance and results in effector CTL generation. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246499
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