CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
The activation of the hepatic innate immune system by siRNA is controlled by chemical modifications and may involve endosomal Toll-like receptors
DOI 10.1055/s-0029-1246501
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Nachweis in CareLit
Autor:innenR Bröring, M John, K Kleinehr, JP Sowa, A Bucchi, G Gerken, JF Schlaak
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: siRNAs are being developed for the therapeutic use in liver cancer, viral hepatitis or metabolic disorders. Undesired immune stimulation of siRNA are usually studied in human cell lines or PBMC. Here, we assessed the capacity of chemically modified versus unmodified siRNAs to trigger immune responses in primary human cells of the liver. Methods: siRNAs targeting APOB1 (APO, APO-chol) and control siRNAs targeti…
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Zitierempfehlung
R Bröring, M John, K Kleinehr, JP Sowa, A Bucchi, G Gerken, JF Schlaak (2010) The activation of the hepatic innate immune system by siRNA is controlled by chemical modifications and may involve endosomal Toll-like receptors. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246501
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