CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Analysis of HCV-specific CD8+ T-cell cytolytic effector functions and their contribution to antiviral efficacy using a novel immunological model
DOI 10.1055/s-0029-1246515
Bibliografische Angaben
Nachweis in CareLit
Autor:innenJ Jo, SJ Rau, U Aichele, L Joeckel, C Borner, E Bisse, T Baumert, HE Blum, R Fischer, V Lohmann, R Thimme
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Recently, we developed a novel model for studying HCV immunology (Gastroenterology, 2009). We observed that HCVspecific CD8+ T cells strongly inhibit viral replication through cytolytic and non-cytolytic mechanisms. While the non-cytolytic effects were primarily mediated by IFN-gamma, the mechanisms and the relative contribution of cytolysis to antiviral efficacy were not investigated. To address these important que…
Zitieren
Zitierempfehlung
J Jo, SJ Rau, U Aichele, L Joeckel, C Borner, E Bisse, T Baumert, HE Blum, R Fischer, V Lohmann, R Thimme (2010) Analysis of HCV-specific CD8+ T-cell cytolytic effector functions and their contribution to antiviral efficacy using a novel immunological model. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246515
Mit CareLit weiterarbeiten