CareLit · DOI-Nachweis · Zeitschrift für Gastroenterologie
Iron-induced expression of BMP6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo
DOI 10.1055/s-0029-1246548
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Autor:innenS Arndt, U Mägdefrau, C Dorn, K Schardt, AK Bosserhoff, C Hellerbrand
ZeitschriftZeitschrift für Gastroenterologie
Ausgabe01/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Recent studies identified bone morphogenic protein 6 (BMP6) as key regulator of hepatic hepcidin expression and iron metabolism but the cellular source of BMP6 and the reason for its specific effect on hepatocytes are unknown. Methods and Results: BMP6-/- mice on a 129Sv/Ev background fed with normal diet develop severe hepatic iron accumulation and reduced hepcidin expression with increasing age. This phenotype cou…
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Zitierempfehlung
S Arndt, U Mägdefrau, C Dorn, K Schardt, AK Bosserhoff, C Hellerbrand (2010) Iron-induced expression of BMP6 in intestinal cells is the main regulator of hepatic hepcidin expression in vivo. Zeitschrift für Gastroenterologie (01). https://doi.org/10.1055/s-0029-1246548
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