α The generation and importance of circadian rhythms through the action of clock genes in the endocrine pancreas

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Higher vertebrates have evolved mechanisms to measure time and to adopt body functions to the physical change of night and day. These so-called „biological clocks“ generate a rhythm with a phase length (τ) of approximately 24 hr. To adjust these „circa-dian“ clocks to the exact 24h day, these endogen biological clocks need to be adjusted, or synchronized. In mammals, the central circadian oscillator is localized in…

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