Influence of melatonin on secretion rhythms and signal-transduction processes in the pancreatic β-cell: melatonin–insulin interactions

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Recently, many investigations on the functional interactions between the pineal gland and glucose metabolism have been collected: (i) Melatonin influences insulin secretion and, in general, decreases insulin secretion both in vivo and in vitro. Moreover, the effects of melatonin on insulin secretion have been shown to be receptor mediated. Expression of the melatonin receptor MT1 and, more recently, that of the MT2…

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