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Mechanisms for regulation of brain mitochondria by extramitochondrial Ca2+ as new targets of neurodegeneration

FN Gellerich, Z Gizatullina, HP Nguyen, S Trumbeckaite, S Nuber, M Jucker, F Striggow · Klinische Neurophysiologie · Ausgabe 03/2010

DOI 10.1055/s-0030-1251023

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Autor:innenFN Gellerich, Z Gizatullina, HP Nguyen, S Trumbeckaite, S Nuber, M Jucker, F Striggow
ZeitschriftKlinische Neurophysiologie
Ausgabe03/2010
Jahrgang / SeitenNicht angegeben

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Abstract-Vorschau

Due to complex interactions between mitochondria and other cell compartments there are diverse possibilities for involvement of mitochondria in the pathophysiology of neurodegeneration (1). Recently we detected for the first time at isolated muscle mitochondria of R6/2 mice an increased sensitivity of OXPHOS against Ca2+-stress (2). Therefore we systematically investigated the role of cytosolic Ca2+ (Ca2+ cyt) for t…

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FN Gellerich, Z Gizatullina, HP Nguyen, S Trumbeckaite, S Nuber, M Jucker, F Striggow (2010) Mechanisms for regulation of brain mitochondria by extramitochondrial Ca2+ as new targets of neurodegeneration. Klinische Neurophysiologie (03). https://doi.org/10.1055/s-0030-1251023

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