CareLit · DOI-Nachweis · Pneumologie
A NLRP3 inflammasome as well as Rac1 mediate IL-1beta production in C. pneumoniae-infected human monocytes
DOI 10.1055/s-0030-1251251
Bibliografische Angaben
Nachweis in CareLit
Autor:innenB Opitz, J Eitel, C Orlovski, K Meixenberger, C Buss, N Suttorp
ZeitschriftPneumologie
Ausgabe03/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Chlamydophila pneumoniae cause respiratory tract infections and has been associated with development of asthma and atherosclerosis. The innate immune system recognizes C. pneumoniae via TLR2, TLR4 and NOD1/2 and thus initiates a NF-κB-driven gene expression of e.g. proIL-1β. proIL-1β needs subsequently to be processed to mature IL-1β by multiprotein complexes called inflammasomes which are formed by NOD-like recepto…
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Zitierempfehlung
B Opitz, J Eitel, C Orlovski, K Meixenberger, C Buss, N Suttorp (2010) A NLRP3 inflammasome as well as Rac1 mediate IL-1beta production in C. pneumoniae-infected human monocytes. Pneumologie (03). https://doi.org/10.1055/s-0030-1251251
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