CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
DPP-4 inhibitors enhance GIP and attenuate GLP-1 incretin effects during IVGTT in Wistar rats
DOI 10.1055/s-0030-1253788
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Nachweis in CareLit
Autor:innenEJ Freyse, S Berg, P Heinke, KD Kohnert, E Salzsieder
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
Aims: DPP-4 (dipeptidyl peptidase-4) inhibition has been reported to increase incretin effects of GIP as well as GLP-1 by prolonging their half life. DPP-4 cleaves GIP into dipeptide and the GIP metabolite GIP (3–42), whereas the GLP-1 (7–36) amide is cleaved to GLP-1 (9–36) amide. Based on studies in man, pig and rat, these peptides are involved in various glucoregulatory processes. We have recently developed a tes…
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Zitierempfehlung
EJ Freyse, S Berg, P Heinke, KD Kohnert, E Salzsieder (2010) DPP-4 inhibitors enhance GIP and attenuate GLP-1 incretin effects during IVGTT in Wistar rats. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0030-1253788
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