CareLit · DOI-Nachweis · Diabetologie und Stoffwechsel
Novel and known variants in PCSK1 – Functional characterization and clinical associations with obesity in children
DOI 10.1055/s-0030-1253973
Bibliografische Angaben
Nachweis in CareLit
Autor:innenA Körner, D Löffler, J Creemers, R Tauscher, J Kratzsch, J Klammt, P Kovacs, W Kiess
ZeitschriftDiabetologie und Stoffwechsel
Ausgabe04/2010
Jahrgang / SeitenNicht angegeben
Kernaussage aus der Literatur
Abstract-Vorschau
PCSK1 is a physiologic candidate gene for obesity with support from rare monogenic cases and recent association studies. We aimed to screen the gene for novel variants, to assess their effects on obesity and to evaluate their functional relevance in vitro. We sequenced the coding region and 5′UTR in 52 obese children selected for high proinsulin and early impaired glucose tolerance. We identified 8 known SNPs and 2…
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Zitierempfehlung
A Körner, D Löffler, J Creemers, R Tauscher, J Kratzsch, J Klammt, P Kovacs, W Kiess (2010) Novel and known variants in PCSK1 – Functional characterization and clinical associations with obesity in children. Diabetologie und Stoffwechsel (04). https://doi.org/10.1055/s-0030-1253973
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